2001 - Chromatography Chiral Separation Techniques - A Pratical Approach (2nd Ed) - G. Subramanian

Please download to get full document.

View again

of 347
All materials on our website are shared by users. If you have any questions about copyright issues, please report us to resolve them. We are always happy to assist you.
Information Report
Category:

Documents

Published:

Views: 2 | Pages: 347

Extension: PDF | Download: 0

Share
Related documents
Description
Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.
Tags
Transcript
  ChiralSeparation Techniques Edited byG. Subramanian Chiral Separation Techniques:A Practical Approach,Second,completely revised and updated edition Edited by G. SubramanianCopyright © 2001 Wiley-VCH Verlag GmbHISBNs:3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)  ChiralSeparation Techniques A Practical Approach Second,completely revised and updated editionEdited byG. Subramanian Weinheim · Chichester · New York · Toronto · Brisbane · Singapore Chiral Separation Techniques:A Practical Approach,Second,completely revised and updated edition Edited by G. SubramanianCopyright © 2001 Wiley-VCH Verlag GmbHISBNs:3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)  Dr. Ganapathy Subramanian60B Jubilee RoadLittlebourneCanterburyKent CT3 1TP,UK Library of Congress Card No. applied forA catalogue record for this book is available from the British LibraryDie Deutsche Bibliothek – CIP Cataloguing-in-Publication-DataA catalogue record for this publication is available from Die Deutsche Bibliothek ©WILEY-VCH Verlag GmbH,D-69469 Weinheim (Federal Republic of Germany),2001ISBN 3-527-29875-4Printed on acid-free paper.All rights reserved (including those of translation in other languages). No part of this book may bereproduced in any form – by photoprinting,microfilm,or any other means – nor transmitted ortranslated into machine language without written permission from the publishers. Registered names,trademarks,etc. used in this book,even when not specifically marked as such,are not to be con-sidered unprotected by law.Composition:TypoDesign Hecker GmbH,D-69181 LeimenPrinting:Strauss Offsetdruck,D-69509 MörlenbachBookbinding:Osswald & Co.,D-67433 Neustadt (Weinstraße)Printed in the Federal Republic of Germany.This book was carefully produced. Nevertheless,authors,editor,and publisher do not warrantthe information contained therein to be free of errors. Readers are advised to keep in mind thatstatements,data,illustrations,procedural details or other items may inadvertently be inaccurate. Chiral Separation Techniques:A Practical Approach,Second,completely revised and updated edition Edited by G. SubramanianCopyright © 2001 Wiley-VCH Verlag GmbHISBNs:3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)  During the past two decades there has been intense interest in the development andapplication of chiral chromatographic methods,particularly in the pharmaceuticalindustries. This is driven both by desire to develop and exploit “good science”andby the increasing pressure by regulatory authorities over the past ten years againstthe marketing of racemic mixtures. The regulation of chiral drug provides a gooddemonstration of the mutual relationship between progress in scientific methodologyand regulatory guidelines. It has also provided a common platform in establishinggood understanding between international regulatory authorities and pharamceuticalindustries,leading to a consensus in recognition of the global nature of pharmaceu-tical development. This has provided a great challenge for the industries to seek techniques that are efficient,economical and easy to apply,in the manufacture of enantiopure products.The versatility of chiral stationary phases and its effecitve application in both ana-lytical and large-scale enantioseparation has been discussed in the earlier book ‘  APractical Approach to Chiral Separation by Liquid Chromatography ’(Ed. G. Sub-ramanian,VCH 1994). This book aims to bring to the forefront the current develop-ment and sucessful application chiral separation techniques,thereby providing aninsight to researchers,analytical and industrial chemists,allowing a choice of methodology from the entire spectrum of available techniques.I am indebted to the leading international group of contributors,who have agreedto share their knowlegde and experience. Each chapter represents an overview of itschosen topic. Chapter 1 provider an overview of techniques in preparative chiral sep-aration,while Chapter 2 provides an account on method development and optimisa-tion of enantiomer separation using macrocyclic glycopeptide chiral stationaryphase. Combinatorial approach and chirabase applications are discussed in Chapters3 and 4. Chapter 5 details the development of membranes for chiral separation,whileChapter 6 gives an overview of implanting techniques for enantiopurification. Nonchromatographic solid-phase purification of enantiomers is explained in Chapter 7,and Chapter 8 discusses modeling and simulation of SMB and its application inenantioseparation. A perspective on cGMP compliance for preparative chiral chro-matography in discussed Chapter 9,and Chapter 10 provides an account of elec-trophoretically driven preparative chiral separation and sub- and supercritical fluid Preface Chiral Separation Techniques:A Practical Approach,Second,completely revised and updated edition Edited by G. SubramanianCopyright © 2001 Wiley-VCH Verlag GmbHISBNs:3-527-29875-4 (Hardcover); 3-527-60036-1 (Electronic)
Recommended
View more...
We Need Your Support
Thank you for visiting our website and your interest in our free products and services. We are nonprofit website to share and download documents. To the running of this website, we need your help to support us.

Thanks to everyone for your continued support.

No, Thanks
SAVE OUR EARTH

We need your sign to support Project to invent "SMART AND CONTROLLABLE REFLECTIVE BALLOONS" to cover the Sun and Save Our Earth.

More details...

Sign Now!

We are very appreciated for your Prompt Action!

x